I think it depends on quite a few factors. I just bought a Suzuki, but I would have been happy with an Etec, an Opti, or the Suzuki. It came down to the price... several thousand better. Speaking of which, there is a gentleman in Hudson who may still have a 225 or 250 Suzuki leftover.
Now to be fair to Suzuki, the weight difference between it and an Etec are small... A 25" shaft 225 Etec is 525lbs, while Suzuki comes in at 580lbs. IMO that's not a decision point. Now some other 4strokes do weight more... notably the Verados.
The real question is do you want two or four stroke? Both have disadvantages... I am not thrilled about having a valvetrain on my outboard- but it is a chain driven cam at least. Oil changes are not a huge deal, but they are regular maintenance. On the two stroke side, you have to watch for carbon buildup... there are a lot of debates about that- but trust me, after building small two stroke motors for years, I know that carbon buildup is not a fallacy. The other drawback to two strokes is that they all rely on high pressure direct injection. This makes them more efficient, but if the pump goes out, it's $1k minimum.
Sit back, read up on both, and make an educated decision. Once again, I was so torn between the two that it came down to which was the best deal. I doubt you will be disappointed with either.